A gene in some apes can help to encourage vaccine protection against simian immunodeficiency virus (SIV) and can assist researchers in developing an AIDS vaccine is more good in people.
In the study, the results published this week, the researchers injected the vaccine into a group of rhesus monkeys and then spoil it with SIV animal repeatedly over the past two weeks. Half of the infected, but half were not. Apes are immune to infection have identified a TRIM5 gene.
These findings may help researchers in conducting searches that are difficult to develop a vaccine to deal with the human immunodeficiency virus (HIV), which causes AIDS, said the study's lead author Norman Letvin, as reported by AFP. "That tells us that perhaps in some humans there are certain genes that can help to protect," said Levin, a professor at Harvard Medical School.
"Therefore, we not only have to examine the anti-body reaction that is injected by the vaccine but we also must examine the genetic composition of individuals who were given the vaccine because the data in monkeys indicate they can contribute," he said. The study is published in the journal Science Transnational Medicine.
One trial of AIDS vaccine on humans in Thailand in 2009 showed some fortress against HIV - 31.2 percent reduction in risk - but its effectiveness declined after three years, says Letvin. "We have shown the vaccine trials in Thailand that with today's technology we see the simplest protection against HIV transmission," he said.
"If only we were optimistic that integrate data in humans with type of data we collected in the study in monkeys, as well as other studies in monkeys. It shows if we can inject a better antibody response through vaccination, perhaps the next generation of vaccines that we can raise the level of chance of 50 or 60 percent or even higher. And that protection may be more of cure, "he said.
Search continues for vaccines to deal with AIDS, which has claimed more than 25 million people since 1981 and infect as many as 33 million people around the world.
Source: between / AFP
In the study, the results published this week, the researchers injected the vaccine into a group of rhesus monkeys and then spoil it with SIV animal repeatedly over the past two weeks. Half of the infected, but half were not. Apes are immune to infection have identified a TRIM5 gene.
These findings may help researchers in conducting searches that are difficult to develop a vaccine to deal with the human immunodeficiency virus (HIV), which causes AIDS, said the study's lead author Norman Letvin, as reported by AFP. "That tells us that perhaps in some humans there are certain genes that can help to protect," said Levin, a professor at Harvard Medical School.
"Therefore, we not only have to examine the anti-body reaction that is injected by the vaccine but we also must examine the genetic composition of individuals who were given the vaccine because the data in monkeys indicate they can contribute," he said. The study is published in the journal Science Transnational Medicine.
One trial of AIDS vaccine on humans in Thailand in 2009 showed some fortress against HIV - 31.2 percent reduction in risk - but its effectiveness declined after three years, says Letvin. "We have shown the vaccine trials in Thailand that with today's technology we see the simplest protection against HIV transmission," he said.
"If only we were optimistic that integrate data in humans with type of data we collected in the study in monkeys, as well as other studies in monkeys. It shows if we can inject a better antibody response through vaccination, perhaps the next generation of vaccines that we can raise the level of chance of 50 or 60 percent or even higher. And that protection may be more of cure, "he said.
Search continues for vaccines to deal with AIDS, which has claimed more than 25 million people since 1981 and infect as many as 33 million people around the world.
Source: between / AFP
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